association of il-10 gene polymorphisms and human t lymphotropic virus type i-associated myelopathy/tropical spastic paraparesis in north-east of iran (mashhad)
نویسندگان
چکیده
the underlying mechanisms leading to the development of human t-cell lymphotropic virus type i (htlv-i) associated myelopathy/tropical spastic paraparesis (ham/tsp) in htlv-i infected individuals are not fully understood. host genetic factors appear to be involved as risk factors for developing ham/tsp. we investigated the possible contribution of interleukin-10 (il-10) as a risk factor to ham/tsp by comparing frequencies of promoter region single nucleotide polymorphisms in htlv-i infected iranian patients who either remained asymptomatic or developed ham/tsp and asymptomatic htlv-i carriers. healthy, uninfected individuals from the same region served as healthy controls. significant differences were observed in the distribution of il-10 promoter alleles and genotypes at position -819 and -592 between ham/tsp patients and healthy controls (p=0.01), and between htlv-i carriers and healthy controls (p=0.02). the frequency of the low il-10 producer haplotype (-1082*a, -819*t, -592*a) was significantly associated with htlv-i carriage or ham/tsp compared with healthy controls (p= 0.02 and 0.01, respectively). our results suggest that il-10 -819*t and -592*a alleles are significant risk factors for developing htllv-i infection but do not appear to convey additional risk for developing ham/tsp
منابع مشابه
Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad)
The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear to be involved as risk factors for developing HAM/TSP. We investigated the possible contribution of interleukin-10 (IL-10) as a risk factor to HA...
متن کاملAssociation of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad)
The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear to be involved as risk factors for developing HAM/TSP. We investigated the possible contribution of interleukin-10 (IL-10) as a risk factor to HAM/...
متن کاملPolymorphism in the interleukin-10 promoter affects both provirus load and the risk of human t lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis
To investigate candidate genes that influence the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed 6 single nucleotide polymorphisms (SNP) in the interleukin-10 (IL-10) promoter region. METHODS: 280 cases of HAM/TSP patients and 255 HTLV-I seropositive asymptomatic carriers (HCs) from Kagoshima, Japan were studied. All subjects gave written informed conse...
متن کاملPolymorphism in the interleukin-10 promoter affects both provirus load and the risk of human t lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis
To investigate candidate genes that influence the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed 6 single nucleotide polymorphisms (SNP) in the interleukin-10 (IL-10) promoter region. METHODS: 280 cases of HAM/TSP patients and 255 HTLV-I seropositive asymptomatic carriers (HCs) from Kagoshima, Japan were studied. All subjects gave written informed conse...
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عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۶، شماره ۳، صفحات ۲۵۸-۲۶۳
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